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XPERIENCE® Advanced Surgical Irrigation

XPERIENCE® Advanced Surgical Irrigation

Advanced Surgical Irrigation

XPERIENCE® is a no-rinse surgical solution. It is designed to rinse away debris and microorganisms that may cause post-operative complications.

For healthcare professional use only ARTG listed Distributed in Australia by Novus Surgical
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XPERIENCE® Advanced Surgical Irrigation bottles
5 hrsof ongoing protection against bacteria*
99.9%bacterial elimination*
No rinseNo secondary rinse out required, which may reduce surgery time

*When used per the IFU.

Features

A no-rinse surgical solution

XPERIENCE® Advanced Surgical Irrigation is indicated for use in cleansing and removal of debris, including microorganisms, from wounds.

No secondary rinse out required, which may reduce surgery time.

Contains: Sodium Lauryl Sulfate, Citric Acid, Sodium Citrate and Water.
  • 5 hours of ongoing protection against bacteria*
  • No secondary rinse out required, which may reduce surgery time
  • Non-toxic
  • Broad spectrum efficacy within the solution*
  • No known bacterial resistance
  • 99.9% bacterial elimination*
  • Compatible with most commonly used implants and closure methods†

*When used per the IFU. †Does not include hydroxyapatite (HA) or fibrin sealants.

How it works

How XPERIENCE® works

The technology deconstructs the biofilm that enters into the solution by removing the metal ions holding the polymer together and destroys the enveloped bacteria. XPERIENCE® defends against bacterial recolonisation.

1

Deconstruction

Loosening the extracellular polymeric substance (EPS) structure by binding the metal ions that link its polymer strands.

2

Dislodgement

Once the matrix is loosened, microorganisms and debris can be more readily dislodged and flushed from the wound.

3

Defence

Biofilm can re-emerge within days of debridement, which is why limiting recolonisation matters.

Understanding biofilm

What is biofilm?

A community of microbes encased within a complex structure of entangled polymers strengthened with metal ions.

Biofilm attaches to both living surfaces (e.g. wounds, mucosal tissue) and non-living surfaces (e.g. implants, surgical hardware, catheters).2

~80%of bacteria are estimated to exist within biofilm communities1
~20%exist in a free-floating (planktonic) state1
Surgical team operating under theatre lights
Clinical significanceBiofilm is considered the dominant mode of microbial growth.1
Community of microbes
Multiple species of bacteria and fungi living together.2
Entangled polymers
Microbes secrete a protective matrix called EPS (extracellular polymeric substance) made from polymers including proteins, glycolipids, polysaccharides and DNA.1,2
Metal ions
Metal ions link polymers of the EPS, forming a resilient barrier.
Why biofilm is harder to treat
  • The EPS matrix physically blocks antibiotics and antiseptics.1
  • The immune system struggles to reach organisms sheltered within the matrix.2
  • Some bacteria become dormant, or metabolically inactive, and can reactivate later.1,2
  • Bacteria within a biofilm can exchange genetic material, including resistance genes.2
XPERIENCE® compatibility with commonly used implants and closure methods
Compatibility

Compatible with most commonly used implants and closure methods†

Acceptable for use with coated hydroxyapatite (HA) implants. Do not use with solid hydroxyapatite due to the risk of accelerated material degradation.

Do not use with fibrin sealants due to the risk of material degradation. Application of fibrin sealants in the presence of XPERIENCE® Advanced Surgical Irrigation may impact sealant setup.

†Does not include hydroxyapatite (HA) or fibrin sealants.

Clinical evidence

Clinical studies

Published and ongoing clinical research evaluating XPERIENCE® Advanced Surgical Irrigation.

ZeroDeep incisional SSI: Singer, R. (MD), 2023
ZeroOrgan/space SSI: Singer, R. (MD), 2023
ZeroDelayed/late PJI: Singer, R. (MD), 2023
Ongoing

Multicenter randomized controlled trial

Evaluating XPERIENCE™ Advanced Surgical Irrigation on risk of periprosthetic joint infection following hip and knee replacement surgery. Sponsored by the Ottawa Hospital Research Institute (ClinicalTrials.gov: NCT05543941).

2025

Wood, R. et al.

The Use of a Novel Antiseptic Irrigant Solution in Combination with Vancomycin Powder Significantly Reduces the Risk of Surgical Site Infections in Orthopedic Trauma Patients.

2024

Bashyal, R. and Vatti, L. et al.

The Use of a Novel Surgical Irrigant May Be Associated with Decreased Incidence of Surgical Site Infections.

2023

Singer, R.

Efficacy of XPERIENCE Advanced Surgical Irrigation in Preventing Deep Surgical Site Infections and Periprosthetic Joint Infections in Primary Total Knee Arthroplasty.

Safety information

Warnings & precautions

XPERIENCE® has been safety tested showing no irritation.

Always read the label and follow the instructions for use. This medical device must be administered by a healthcare professional.
Warnings / precautions
  • NOT FOR IV USE. This product has been tested as a wound wash only. DO NOT inject.
  • External use only.
  • The product is single-use and should be applied only once in a 24-hour period.
  • Discard any unused solution.
  • Do not use if there is a history of allergy to any of the ingredients.
  • Avoid eye contact; product may cause ocular irritation.
  • Do not use if container is damaged.
  • Potential for temporary burning or discomfort may occur.
  • Do not use with fibrin sealants due to the risk of material degradation. Application of fibrin sealants in the presence of XPERIENCE® Advanced Surgical Irrigation may impact sealant setup.
  • Acceptable for use with coated hydroxyapatite (HA) implants. Do not use with solid hydroxyapatite due to the risk of accelerated material degradation.
  • If product contacts unintended anatomy or materials, rinse away solution after irrigation.
  • The Stryker StrykeFlow II laparoscopic irrigator does not provide adequate pressure to remove debris when used with XPERIENCE® Advanced Surgical Irrigation.
  • Do not use in the case of substantial tissue loss.
  • Use of citrates may result in QT prolongation and other signs of short-term hypocalcaemia due to the ability for citrate to chelate ionised calcium.
Product information

Resources

Full technical, clinical and safety documentation is available for healthcare professionals.

ARTG Certificate

Download →

Instructions for Use

Download →

Ordering Information

Download →

Safety Data Sheet

Download →
The information about XPERIENCE® is intended for Australian and New Zealand healthcare professionals (HCPs) only. The product displayed on this website is only available for sale to healthcare professionals. Access by non-healthcare professionals is not authorised. XPERIENCE® IS NOT AVAILABLE FOR PURCHASE BY THE GENERAL PUBLIC.

Questions about XPERIENCE® in Tasmania?

XPERIENCE® is distributed in Australia by Novus Surgical. TechnoMed is the Tasmanian representative for XPERIENCE® Advanced Surgical Irrigation.

Contact TechnoMed Visit Novus Surgical

Disclaimers

ALWAYS READ THE LABEL AND FOLLOW THE INSTRUCTIONS FOR USE. XPERIENCE® is intended for use by healthcare professionals only. Full technical, clinical and safety documentation, including its ARTG entry and Instructions for Use, is available via the resources above or through your TechnoMed or Novus Surgical representative.

This page provides general scientific information and is not intended as medical advice. It does not constitute a recommendation for the diagnosis, treatment or management of any condition. Clinical decisions regarding infection prevention should be made in consultation with a qualified healthcare professional.

XPERIENCE® is a registered trademark of its respective owner. Product images supplied courtesy of Novus Surgical.

References

  1. Penesyan A, et al. Three faces of biofilms: a microbial lifestyle, a nascent multicellular organism, and an incubator for diversity. NPJ Biofilms Microbiomes. 2021;7(1):80.
  2. Omar A, et al. Microbial Biofilms and Chronic Wounds. Microorganisms. 2017;5(1):9.
  3. Thoendel MJ, et al. Identification of Prosthetic Joint Infection Pathogens Using a Shotgun Metagenomics Approach. Clin Infect Dis. 2018;67(9):1333-1338.
  4. Bashyal, R.K. et al. (2022) A novel irrigant to eliminate planktonic bacteria and eradicate biofilm superstructure with persistent effect during total hip arthroplasty. The Journal of Arthroplasty, 37(7). doi:10.1016/j.arth.2022.01.045.
  5. Gupta K, Marques C, Petrova OE, Sauer K. Antimicrobial tolerance of Pseudomonas aeruginosa biofilms is activated during an early developmental stage and requires the two-component hybrid SagS. J Bacteriol. 2013;195(21):4975-4987.
  6. Leid JG, Willson CJ, Shirtliff ME, et al. The exopolysaccharide alginate protects Pseudomonas aeruginosa biofilm bacteria from IFN-mediated macrophage killing. J Immunol. 2005;175(11):7512-7518.
  7. Williams DL. Targeting biofilms in translational research, device development, and industrial sectors. 2019.
  8. Data on file: TR-04-21-008, TR-04-21-009; TR-06-19-012, TR-12-19-002; TR-06-19-007; TR-01-21-003, CD-0040.